Customer Spotlights

We are dedicated to developing and supporting instrumentation that enables a broad range of applications for scientists around the world. We can tell you about how BioTek instrumentation can benefit your research, but we’d rather you hear it directly from our customers! Browse the Customer Spotlights below to see how BioTek is helping to make their research possible.

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Lionheart FX

Cytation and Lionheart Help to Identify cFLIPL as a Key Regulator of Cell Death and Inflammation

21-April-20
Related Products: Lionheart FX, Cytation 3

At Tufts University’s Graduate School of Biomedical Sciences, Dr. Alexander Poltorak seeks to understand how the host immune system responds when facing a pathogen. If the response is too strong or too weak, the results can be devastating. “If we look at the SARS-CoV-2 virus impacting the world right now, many deaths aren’t a direct result of the coronavirus itself,” he says. “Instead, it’s a complication of the infection; a violent, unbalanced response from the immune system resulting in many different pathological processes or attacks taking place in the lungs.”

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Sensory Neurons

Time to Accelerate the Pace of Neurobiology Research

25-March-20
Related Products: Cytation 1

Differentiating a stem cell into a neuron or glial cell is typically a time-consuming bottleneck in human neurological dysfunction research. On top of this, precisely controlling the purity of sub-types in a mixed neuron population can be a complex task, yet is critical to improve assay reproducibility and eliminate unwanted cell types that may negatively impact results.

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CCHE

Activating Lasting Change in Childhood Cancer Treatments

04-March-20
Related Products: Cytation 5

In 2007, the Children’s Cancer Hospital Egypt (CCHE) 57357 was established to create a better tomorrow for children facing a devastating cancer diagnosis. As the largest pediatric oncology hospital in the world, the center offers best-in-class treatment therapies along with comprehensive family-centered quality care. In addition to clinical and wellness services, CCHE is also home to a wealth of cutting-edge researchers focused on improving clinical outcomes and reducing adverse therapeutic events.

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VCFG

Expanding Research Power and Flexibility within Australia’s Biomedical Research Community

27-February-20
Related Products: Cytation 5, BioSpa 8, MultiFlo FX, BioStack, EL406

The Victorian Centre for Functional Genomics (VCFG) supports and propels research efforts across Australia. Located at the Peter MacCallum Cancer Centre in Melbourne, Victoria, this core facility’s ”researcher driven, staff assisted” ethos is carried through all services, from conception and grant writing to multi-platform, high-throughput screening and analysis. In addition to having a strong collaborative effort, the wide diversity of researcher goals means that the facility must remain at the leading edge of innovations in science and technology.

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DiscoveryBioMed, Inc.,

Exploring New Boundaries in Humanized Drug Discovery

18-November-19
Related Products: Synergy HT, Synergy Neo, Cytation 5, BioSpa 8, MultiFlo FX

DiscoveryBioMed, Inc., supplies products and services to help the drug discovery community improve attrition rates and pinpoint compounds that are high-value clinical candidates. Since its founding in 2007 by physiologist Dr. Erik Schwiebert, this Birmingham, Alabama based company’s novel ‘Humanized Drug Discovery’ approach identifies and develops highly relevant diseased and normal human cell models, and integrates them along every step in the drug discovery critical path. The company has expertise in several areas of custom cell engineering and cell-based drug discovery, particularly in human renal, respiratory, and metabolic systems.

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denovoMATRIX

Discovering New Ways to Advance Cell Biology Research with Lionheart FX

16-August-19
Related Product: Lionheart FX

Creating an in vitro environment that is highly similar to that found in the body, including the presence of an extracellular matrix (ECM), is a critical aspect of reaping the most relevancy from cell-based research. Often, researchers find that optimizing culture environments is a time-consuming and costly process. The team at denovoMATRIX GmbH in Dresden, Germany, seeks to ease this burden by developing and manufacturing novel, pre-coated cultureware for specific cell types. Dr. Dejan Hušman,  CEO of denovoMATRIX,  explains that the specialized coatings used on the cultureware are composed of glycosaminoglycans and biomimetic peptides that can be combined to generate entire libraries of extracellular matrices for use in their user-customized myMATRIX and their flagship screenMATRIX products. Dr., Hušman  notes that development of the latter was dependent on their use of BioTek’s Lionheart™ FX Automated Microscope.

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UCA

Cytation Helps to Highlight Synthetic Serum-Free Media Advantages and More

29-June-19
Related Product: Cytation 3

Several years ago, the BIORCELL3D collaborative research project was launched by three partners:  Clermont Auvergne University (UCA, France) through the Resistance Team of UMR INSERM 1240 Molecular Imaging and Theranostic Strategies (IMoST) located in the University Institute of Technology; BIOPASS company; and BIOMARQUEURS company. The project goals are to develop large-scale, biosimilar three-dimensional (3D) tumoroid and organoid models for use in developing anticancer strategies and screening new targeted therapies. These alternative culture models need highly controlled conditions, yet a known challenge to cell culture reproducibility is establishing homogeneity in the culture media, especially when supplemented with fetal calf serum (FCS). As one of the BIORCELL 3D partners, BIOPASS developed the OptiPASS synthetic cell culture medium to bypass reproducibility issues associated with the use of fetal calf serum.

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Williams

Zebrafish and Lionheart: A Perfect Match

8-May-19
Related Product: Lionheart FX

Zebrafish are essential to Dr. Charles (Chaz) Hong’s laboratory at the University of Maryland School of Medicine. Here, these diminutive powerhouses of developmental biology research are used to characterize the chemical biology of vertebrate development, and to also discover novel chemical tools to selectively modulate embryonic development. As a matter of fact, the Hong Lab used zebrafish in their discovery of the world’s first bone morphogenetic protein (BMP) inhibitor, called dorsomorphin which was identified by its ability to make the body of the embryos shorter. Dr. Charles (Chuck) Williams, Assistant Professor of Medicine, who works with the Hong Lab, studies embryonic development in zebrafish using a forward chemical genetic approach. This entails identifying small molecule compounds that interact with proteins important in development. He discovers new biological insights based on how the interaction "breaks" the signals that drive zebrafish development.

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Dr. Jason Stumpff

Teasing Out Fine Details from the Tangled World of Chromosomes

5-April-19
Related Products: BioSpa 8, BioSpa Live Cell Analysis System, Cytation 5

Normal human cells contain 23 chromosome pairs, each encoding the genetic information of life as well as passing on inheritable traits from parents. Chromosomes are tightly folded into origami-like structures that are mind-boggling in their complexity, yet elegantly unfurled and refolded during cell division or mitosis. Tiny errors during mitosis can cause the formation of aneuploid cells containing an abnormal number of chromosomes and lead to miscarriage and health disorders such as Down syndrome. Additionally, these mistakes have been linked to tumorigenesis and accelerated tumor growth rates.

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Green Mountain Antibodies

Confidence in Washing that Lasts for Generations

15-March-19
Related Product: 405 TS

Green Mountain Antibodies, in Burlington, Vermont, offers a wide range of services, including hybridoma and antibody development, protein production and purification, cell culture and assay development for customers around the world. The company’s reputation for attention to detail and quality craftsmanship underscores the drive to operate at peak efficiency, and for Rogelio Zimbron, Laboratory Technician who works on protein purification and high-throughput ELISAs, this means minimizing equipment downtime and unnecessary complexity in laboratory workflows.

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Mimetas

Visualizing Opportunities Through a New Window

30-January-19
Related Product: Cytation 1

Mimetas, based in Leiden, Netherlands, is a pioneer in the rapidly growing organ-on-a-chip industry with their unique OrganoPlate® technology. The OrganoPlate uses a familiar 384-well microplate platform that supports up to 96 individual tissue models. The bottom of the plate is comprised of two layers of optical grade glass separated by a thin layer of microfluidic channels. Pump- and tube-free perfusion supplies media from feed wells through the microfluidic channels to the tissue samples when the plate is placed on a rocker. The user-friendly and high-throughput OrganoPlate benefits users in terms of simplified workflows, improved efficiencies, and increased reproducibility. On top of that, Mimetas offers contracted research services, where they directly apply their organ-on-a-chip technology and expertise according to a customer’s goals and needs.

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Synergy Neo2

Detecting the Rhythms of Life with Synergy Readers

23-January-19
Related Product: Synergy Neo2

Most organisms have circadian clocks, which regulate 24- hour rhythms in a wide variety of activities and behaviors. In humans, the circadian clock regulates sleep onset and influences how much sleep you need. Not surprisingly, changes to these clock factors influence sleep, but also to a wide variety of disorders such as metabolic syndrome, cardiovascular disease, and even cancer. Dr. John Hogenesch, Ohio Eminent Scholar; Professor of Pediatrics in the Divisions of Human Genetics and Immunobiology and the Perinatal Institute; and Deputy Director, Center for Chronobiology at the Cincinnati Children's Hospital Medical Center, in Cincinnati, Ohio, is one of the world’s foremost experts in the molecular mechanisms of circadian rhythms in mammals. His research centers around understanding how biological clocks work and leveraging them to improve human health.

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Dr. Braud

Novel, Highly Sensitive, Non-Radioactive Cytotoxicity Assay with Cytation 5

28-December-18
Related Product: Cytation 5

At the Institut de Pharmacologie Moléculaire et Cellulaire (IPMC) in Nice/Sophia-Antipolis, France, Drs. Fabienne Anjuère and Véronique Braud are on the cutting edge of immunotherapy research with the goals of identifying therapeutic targets and developing innovative vaccines and immunotherapies to treat inflammatory disorders and cancers. Most recently, they are focused on the study of innate immune cells (natural killer cells, neutrophils, dendritic cells) in healthy and tumorigenic epithelial tissues, which requires use of flow cytometry, cellular and biochemical assays in both in vitro and in vivo studies.

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Bananas glow blue

Bananas Glow Blue! Yes, They Do!

14-December-18
Related Product: Cytation 5

Mexico is among the most biodiverse nations in the world, so it stands to reason that top research institutes, such as the Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV) devote special attention towards understanding this biological and genetic diversity to foster renewable sources of energy, nutrition, therapeutics and more. Dr. Axel Tiessen is Head of the Laboratory of Metabolomics and Molecular Plant Physiology at CINVESTAV’s Irapuato, Guanajuato, Mexico campus, and also Head of the National PlanTECC Laboratory. An important aim of his research is to understand major signals that regulate primary metabolism in plants, including responses to environmental factors and physiological inputs.

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Cytation 5

Agilent and BioTek Collaborate on Seahorse XF Normalization

14-December-18
Related Products: Cytation 5, Cytation 1

The power of the well-known Seahorse XF technology from Agilent Technologies lies in its ability to simultaneously and kinetically measure mitochondrial respiration and glycolysis – two major energy pathways – in live cells. By doing so, researchers can closely monitor these dynamic events in real time rather than using separate assays for each cellular activity. As mitochondrial respiratory rates correlate to cell number, small differences in the number of adherent cells present in each microplate well create differences in the data gleaned from the Seahorse XF workflow. Normalizing XF data allows researchers to compare experimental data from well-to-well, treatment-to-treatment, plate-to-plate and more.

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Associate Professor Chioma Okeoma

Understanding Novel Oncogenic Regulators in Breast Cancer with the Lionheart™ FX
SelectScience Interview

18-September-18 video
Related Product: Lionheart FX

Scientists at Stony Brook University, New York, have discovered that the previously known antiviral protein BST2, also known as tetherin or CD371, functions as an oncogenic driver in breast cancer-promoting cell adhesion, growth, migration and invasion of tumor cells.

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When Images are Worth More Than a Thousand Words

When Images are Worth More Than a Thousand Words

13-July-18
Related Products: Cytation 5, Gen5, Synergy 2, ELx405

Cayman Chemical in Ann Arbor, Michigan manufactures and supplies small molecules, assay kits, proteins, and antibodies for biomedical research; while also providing bioanalysis and custom assay development services as part of their menu of contract services. By employing this multi-pronged approach, they enable researchers across the globe to answer complex questions that ultimately support human and animal health. Julie Rumble, Scientist I and Laboratory Operations Coordinator at Cayman Chemical, takes a similar approach with a focus on cell-based assays in her dual R&D and contract services roles.

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Vogel and Wise Lab

Opening New Doors in Cancer Research

13-July-18
Related Products: Cytation 5, Gen5

ATP-binding cassette (ABC) transporters move substrates across cell membranes and are of great importance to those researching cancer and cancer therapies. The laboratories of Dr. Pia Vogel and Dr. John Wise in the Department of Biological Sciences and the Center for Drug Discovery, Design and Delivery (CD4) at the Southern Methodist University in Dallas, TX, are particularly interested in the ABC transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP).

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Stony Brook University

Understanding Breast Cancer – Using Advanced Imaging to Unravel its Molecular Secrets

SelectScience Editorial Article
13-July-18
Related Product: Lionheart FX

Breast cancer is the most common form of cancer in women worldwide, carrying a lifetime risk of approximately 1 in 8. Its incidence is also growing in men, for whom the risk is much less – about 1 in 1,000. The race is on to determine how breast cancer gets started and progresses at the detailed molecular level. Our natural immunity plays a role, in a finely-balanced arms race between protection against external pathogens and over-stimulation leading to cancer. Dr. Chioma Okeoma leads a research team in Stony Brook, New York, dedicated to improving our understanding of how internal host cell factors can either modulate or promote disease in response to external attack, focusing on HIV and breast cancer.

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Synergy Neo2

State-of-the-Art Cellular Screening Facility Enables Efficient Drug Discovery for Academic Labs

SelectScience Editorial Article
17-June-18
Related Product: Synergy Neo2

High-throughput screening plays an important role in both the drug discovery process and in the understanding of disease mechanisms. By measuring the effect that small molecule compounds have on cellular function, we can quickly identify the compounds that have a desired effect and move these molecules forwards in the drug discovery process.

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Mayo

Mechanobiology Lab Extracts New Information, and Great Value, from the Versatile Cytation 5

6-March-18
Related Product: Cytation 5

Fibrosis, a term describing tissue that becomes stiff and scarred, is symptomatic of a number of cardiac, liver and respiratory diseases. A very specific form of fibrosis, known as idiopathic pulmonary fibrosis, is the focus of Dr. Daniel Tschumperlin’s Tissue Repair and Mechanobiology lab at the Mayo Clinic in Rochester, MN. This rare and progressive disease, where lung tissue becomes stiff and scarred without an apparent cause, typically targets an aging population and offers a poor prognosis, as lung function declines and the body cannot receive an adequate oxygen supply.

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Dr. Craig Hodges

Beating Cystic Fibrosis – Perfecting an Intestinal Assay in the Hunt for New Gene Modulators SelectScience Editorial Article
6-December-17
Related Product: Lionheart FX

Cystic fibrosis is a disease which causes immense suffering, and Dr. Craig Hodges and his team in Cleveland, Ohio USA are on the front line in the search for treatments and a cure. Hodges is a cell and developmental biologist and Assistant Professor working at the Case Western Reserve University’s School of Medicine. He works on mouse models of cystic fibrosis, some well-established and others created in his own laboratory. Based in the Department of Paediatrics, his research tackles questions around how specific cell types contribute to the disease and whether those processes can be halted or even reversed. Ultimately, he is on a mission to help either alleviate or eliminate the suffering of cystic fibrosis patients.

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UNIGE

Discovering Nature’s Potential with Cytation 3
20-October-17
Related Product: Cytation 1, Cytation 3, Gen5

In the Pharmacognosy research unit of the School of Pharmaceutical Sciences at the University of Geneva in Switzerland, Dr. Muriel Cuendet’s lab searches for new cancer chemopreventive and antiparasitic agents from the broad chemical diversity found in natural sources.

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Professor Patrick Gunning

Major Drug Discovery Target Offers Promising New Cancer Treatment

SelectScience Editorial Article
13-October-17
Related Product: Cytation 1, Cytation 3

Professor Patrick Gunning discusses the multidisciplinary approach that is helping his team to fast-track the development of small molecules for treating cancer.

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Professor Patrick Gunning

Small Molecule STAT Inhibitors as New Cancer Treatments
SelectScience Interview
6-September-17 video
Related Product: Cytation 1, Cytation 3

In this video, Professor Patrick Gunning discusses his work developing small molecule inhibitors for STAT proteins, with the aim of developing new cancer treatments. STAT-3 is found to be hyperactive in over 70% of human cancer, leading to uncontrolled cell growth, whilst STAT-5 has recently been identified as a target in haematological oncology. The Cytation™ Cell Imaging Multi-Mode Reader by BioTek Instruments, Inc. has been an invaluable instrument within the Gunning laboratory. Learn how it has helped to accelerate drug discovery by enabling the identification of many promising small molecules in pre-clinical trials.

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 Brandt Lab

Fighting Ocular Disease: How Pioneering Virus Research is Spawning Novel Treatments
SelectScience Editorial Article
14-August-17
Related Product: Synergy Neo2

The Brandt Lab in the Department of Ophthalmology and Visual Sciences at the University of Wisconsin-Madison is using the latest technology to carry out innovative research, determining how viral infections happen at a molecular level, and developing novel drugs to stop them. Led by Dr Curtis Brandt, the team is focused on viral gene delivery at sites of infection and development of novel peptides to stop these infections from happening.

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zebrafish

Adding Automated Value to Specialty Zebrafish Assays
9-June-17
Related Product: Cytation 3, Gen5

The city of San Sebastián-Donostia is nestled along the picturesque northern coast of Spain, and is also home to the Contract Research Organization, Biobide. For more than twelve years, Biobide has applied their expertise in the zebrafish animal model to accelerate research and development processes for pharmaceutical, biotechnology, chemical, cosmetic and nutraceutical companies. Their services include developing teratotoxicity, neurotoxicity, cardiotoxicity, hepatotoxicity and other toxicity assays, central nervous system, oncology, immune system related efficacy assays, as well as disease model generation; all as part of preclinical research.

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Dr Francesco Paolo Fiorentino

How Leading Scientists in Italy are Performing State-of-the-Art Cell-Based Assays to Help Push Boundaries in Anticancer Drug Discovery
SelectScience Editorial Article
23-May-17
Related Product: Cytation 5

Dr Francesco Paolo Fiorentino had long dreamed of starting his own company; two years ago, this dream became a reality when he and a colleague applied for and won funding to set up Kitos Biotech. Inspired by a talk from a researcher who had already made the leap from postdoc to entrepreneur, Francesco saw the opportunity to use his expertise in cell biology and preclinical research, whilst also embracing the technological shift from traditional manual methods to automation. Cell-based assay services at Kitos Biotech use the latest automated technologies to test anticancer compounds on a considerably larger scale than traditional manual methods, addressing the need for academic researchers, biotechs, and pharmaceuticals to access costly high-throughput technology.

In an interview with SelectScience®, Dr Fiorentino discussed the technology advancing cell-based assays for anticancer drug discovery and how he is improving services at Kitos Biotech.

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Dr. Eva Kuttner

Improving Joint Health with Putative Therapeutics at Matis, Iceland’s Food & Biotechnology Research Institute
SelectScience Interview
27-April-17
Related Product: Cytation 5

Matis is a leading food and biotechnology research institute in Iceland. Matis’ vision is to increase the value of food processing and food production, and to ensure the safety and quality of food and food products. SelectScience® spoke to Dr. Eva Kuttner, to learn more about the technology the company is using in its research.

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Cytation 5

Leveraging 3D Cancer Stem Cells to Conquer Cancer Relapse
10-April-17
Related Product: Cytation 5

In 2013, Dr. Angel Garcia Martin and Dr. Olatz Leis co-founded StemTek Therapeutics (Bilbao, Spain) as a biopharmaceutical company specializing in cancer stem cell research and drug discovery for novel anticancer therapies. Most chemotherapies and radiotherapies do not target these special cells, which may lead to post-therapy tumor relapse and expansion. Dr. Garcia Martin notes that although finding specific targets in cancer stem cells is complex, they are essential for a durable response in cancer treatment. StemTek eases some of this complexity for researchers by offering in vitro and in vivo screening methods and services based upon their patent-pending Cell2Sphere™ novel compound screening system.

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Dr. Gwendalyn Randolph

Seeing a Clear Slice of Life in Crohn’s Disease
3-April-17
Related Product: Cytation 5

Dr. Gwendalyn Randolph started her career studying immune cell trafficking in and out of tissues, particularly myeloid cells that initiate immune responses and those that derive from monocytes in the blood. In the chronic cardiovascular disease atherosclerosis, she wondered if there was an association between disease progression and the accumulation of myeloid cells because they couldn’t traffic out of the area. As part of this research, she looked at lymphatic vessels, as they drain fluid and traffic certain immune cells to lymph nodes.

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Universidad de La Frontera

Time to move forward with confidence in results
3-April-17
Related Product: Synergy HTX

Dr. Jorge Farías studies cellular and molecular mechanisms in fish spermatozoa as part of his role as the Director of Chemical Engineering at the Universidad de La Frontera in Temuco, Chile. Spermatogenesis, which is the development of sperm, is a delicate balance between cell proliferation, differentiation and apoptosis, and disruptions can have profound implications.

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Kirk McManus

Decreasing Cancer Morbidity Through Colorectal Cancer Research
23-December-16 video
Related Products: Cytation 5, EL406, BioSpa 8

Kirk McManus, Associate Professor, University of Manitoba, and Senior Scientist, CancerCare Manitoba, discusses his ground breaking colorectal cancer research, which aims to minimize the morbidity rates of cancers. Learn how this research is being carried out using an advanced instrument workflow from BioTek, which has streamlined his team's cancer cell studies to great effect. 

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 Dr. Johnson with Miranda Neubert

Dreaming Big When It Comes to the Possibilities
15-December-16
Related Products: Cytation 5

Metals play a very important role in biology, as metal ions are associated with an estimated 40% of all proteins. In bacteria, dedicated acquisition and efflux systems tightly control metal homeostasis. Some metals, such as iron, are so critical to bacterial physiology that in most cases only the acquisition system exists; while others, such as copper, are so toxic that only efflux systems exist. It is this copper toxicity that is of particular interest to Dr. Michael Johnson and his new laboratory in the Department of Immunobiology at the University of Arizona’s College of Medicine. Dr. Johnson notes that although bacteria can develop resistance, as seen against modern antibiotic therapies, they remain vulnerable to the toxic effects of copper. His research aims to unravel this age-old mystery by understanding how copper is toxic to bacteria, and how bacteria overcome copper toxicity.

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Southern Methodist University

Advancing Cancer Research Using High Throughput Screening in Cancer Cell Lines
SelectScience Editorial Article
14-December-16
Related Product: Cytation 5, Gen5, EL406

Amila Nanayakkara, a researcher in the laboratory of Dr Pia Vogel and Dr John Wise in the Department of Biology at the Southern Methodist University of Dallas, spoke to SelectScience® about the lab’s techniques and technologies and how they are used to advance their cancer research. 

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Dr. Katyal

New, Automated Path to Ask More Complicated Questions and Receive Enhanced Answers
27-September-16
Related Products: Cytation 5, Gen5, EL406

With more than a decade of experience, few researchers have more expertise than Dr. Sachin Katyal when it comes to the comet assay, also known as single cell gel electrophoresis (SCGE). As a post-doc at St. Jude Children’s Research Hospital, Dr. Katyal incorporated this assay to study neural damage, and now in his dual role as Assistant Professor in Pharmacology and Therapeutics at the University of Manitoba and Senior Scientist with the Research Institute in Oncology and Hematology (RIOH) at CancerCare Manitoba in Winnipeg, Canada, Dr. Katyal applies the comet assay in his studies on brain tumors and other cancers.

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Erik S.

A Simple Yet Powerful Method for Measuring Real-Time Kinase Activity
14-September-16
Related Products: Synergy Neo2, BioStack

AssayQuant Technologies, Inc., in Marlborough, Massachusetts is a growing Life Science company that develops innovative enzyme assay formats for a quantum improvement in performance and productivity to enable discovery or accelerate drug development. Its founders, Dr. Erik Schaefer and Dr. Barbara Imperiali, each impart a wealth of experience that allows AssayQuant to deliver exceptional value to their customers.

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Charles Teta

MultiFlo FX Wins Over Environmental Lab
14-December-15
Related Product: MutliFlo FX

In the Department of Environmental Science and Health at the National University of Science and Technology (NUST) in Bulawayo, Zimbabwe, Mr. Charles Teta specializes in ecotoxicology. His research includes uncovering the frequency and effects of endocrine disrupting chemicals in native fish, and analyzing hazardous chemicals such as heavy metals and pesticides in the environment that may have originated from municipal landfills, mines and urban effluents. With several kinetic and end-point assay techniques already employed, the manual processes were time consuming, and human error was an ever-present risk when dispensing into a microplate with a single-channel or multi-channel pipette. If reagents were added too slowly, or mixed incompletely, the assays had to be repeated, thereby doubling efforts, sample volume and costly materials.

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City of Hope

A Convenient Jump Start for Anti-tumor Immunity
7-December-15
Related Product: Cytation 3

In the Department of Immuno-Oncology in the Beckman Research Institute at City of Hope National Medical Center, Dr. Marcin Kortylewski and his group incorporate a “flank” strategy in the fight against cancer. Instead of directly focusing on tumor cells, which can evolve over time, the researchers target well-defined immune cell functions. Dr. Kortylewski explains that the immune cell protein, STAT3 (signal transducer and activator of transcription, third member of the family), plays the role of master regulator for normal immune response. STAT3 also performs a similar function when immune cells migrate into the tumor microenvironment. This creates an immunosuppressive effect that prevents a strong anti-tumor response, so blocking this protein can re-energize anti-tumor immunity. His research suggests that oligonucleotide-based therapeutics that inhibit STAT3 in a cell-selective manner may effectively restore the anti-tumor immune response.

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Likarda

More Effective Drug Screening with Cultured 3D Cell Clusters
20-November-15 video
Related Product: Cytation 5

Watch this video to learn more about the drug and product screening process at Likarda, a contract research organization. Dr Lisa Stehno-Bittel, President & CEO of Likarda, discusses the problems of screening drugs for efficacy. Due to the nature of cultured cells, it is very difficult to predict which drugs you’re working with are finally going to work in the human body. By employing the BioTek Cytation 5, Likarda is able to offer the most sophisticated 3D results, efficiently testing drugs in a representative manner.

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Swansea

Biocontrol of Invertebrate Pests Using Natural Agents: Investigating Host-Pathogen Interactions with the BioTek Synergy H1
24-June-15 video
Related Product: Synergy H1

Biocontrol agents provide a safer alternative to chemical pesticides and insecticides for the agricultural and forestry industries, as well as human health. In this video, Dr Bethany Greenfield, Post-Doctoral Research Assistant in the Biocontrol and Natural Products (BANP) Group at Swansea University, describes her research into the use of Metarhizium anisopliae for the control of mosquitoes. Hear how the BioTek Synergy H1 enables the group to efficiently perform a range of analyses, from protein quantification to measuring insect stress response.

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University of Manitoba

University of Manitoba
23-June-15
Related Product: Cytation 3

Like many researchers, Dr. Kirk McManus, Associate Professor in the Department of Biochemistry and Medical Genetics at the University of Manitoba, has many questions, and he and his team are very busy, looking for answers! The main goals of Dr. McManus' primary research area, colorectal cancer, are to a) identify aberrant genes that cause chromosome instability (CIN), and b) once these genes are found, identify new drug targets that exploit the aberrant genes through synthetic lethality.

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Fox Chase Cancer Center

2014 Cytation 3 Contest Winner
07-May-15
Related Product: Cytation 3

It's been a year since Dr. Jeffrey Peterson submitted the winning entry to BioTek’s "Think Possible" contest, earning his laboratory at Fox Chase Cancer Center a new Cytation 3 Cell Imaging Multi-Mode Reader. Here is an excerpt from Peterson's entry:

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Cytation 5

Investigating Novel Therapeutics for Cardiovascular Disease Using the BioTek Cytation 5 Cell Imaging Multi-Mode Reader
SelectScience Editorial Article
10-April-15
Related Product: Cytation 5

Discover how the Director of the Stanford Cardiovascular Institute uses this technology.

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